The development of MDR gram-negative pathogens is multi-factorial. However, experience supports that improving the use of antibiotics in healthcare settings can play an important role in addressing antimicrobial resistance. Although newly approved therapies for CRE infections have been associated with improved patient outcomes compared with older treatment options, their use requires close guidance from ASPs. Antimicrobial stewardship pharmacists are uniquely positioned to help educate and provide guidance to optimize therapy. It is essential to implement policies like antimicrobial stewardship not only to prevent resistant strains but also to improve clinical outcomes and preserve antibiotic utility. Comprehensive education and resources on guidelines should be disseminated to clinicians to ensure compliance and optimal use in clinical practice.
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